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Our technology

Coridon’s patented technology involves the use of:

Unique codon modification

Codons are the triplet nucleotide sequences in DNA and RNA which code for individual amino acids. The genetic code is degenerate in that the majority of amino acids are encoded by more than one codon e.g. there are four codons (GCU, GCA, GCC and GCG) for the amino acid alanine.

It is recognised that modifying the codon composition of a gene can affect the amount of protein produced from its mRNA.  Coridon has developed a unique approach to codon optimisation that takes into account the observation that codon preferences vary according to cell type and differentiation state (Zhao et al., 2005).  In particular, Coridon has compiled a table, termed the Immune Coricode, for maximising the antibody response to intradermally-delivered DNA vaccines.


This refers to the engineering of an antigen gene to include an ubiquitin-encoding sequence.  The ubiquitin targets the antigen to the proteasome for processing into peptide fragments. This leads to an enhanced cellular immune response.

Combination of the two technologies should allow production of DNA vaccines which elicit both a strong antibody response and a robust cellular response. Designed to stimulate both arms of the immune response, the technology is ideally suited not only for the development of prophylactic vaccines but also of therapeutic vaccines.

Background literature:

Liu WJ, Zhao KN, Gao FG, Leggatt GR, Fernando GJP, and IH Frazer (2002) “Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy” Vaccine 20 p862-869.
Zhao KN, Gu WY, Fang NX, Saunders NA, and IH Frazer (2005) “Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo” Molecular and Cellular Biology 25 (19) p8643-8655.
Zhou J, Liu WJ, Peng SW, Sun XY, and IH Frazer (1999) “Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability” Journal of Virology 73 (6) p4972-4982.